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There are about 0.7 to 1.5 million retinal ganglion cells in the human retina. [2] With about 4.6 million cone cells and 92 million rod cells, or 96.6 million photoreceptors per retina, [3] on average each retinal ganglion cell receives inputs from about 100 rods and cones. However, these numbers vary greatly among individuals and as a function ...
In 1974, Boycott and Wassle created a scheme for the classification of Ganglion Cells that was found to be in the cat retina. These cells, alpha, beta, delta and gamma are seen to be linked with the X,Y and W types of physiology. Boycott and Wassle confirmed the idea of Cajal's Ox and Dog retina idea by naming the alpha and beta. In 1978, the ...
[9] [27] The identity of the non-rod, non-cone photoreceptor in humans was found to be a ganglion cell in the inner retina as shown previously in rodless, coneless models in some other mammals. The work was done using patients with rare diseases that wiped out classic rod and cone photoreceptor function but preserved ganglion cell function.
In the anatomy of the eye, the ganglion cell layer (ganglionic layer) is a layer of the retina that consists of retinal ganglion cells and displaced amacrine cells. The cells are somewhat flask -shaped; the rounded internal surface of each resting on the stratum opticum , and sending off an axon which is prolonged into it.
The origin of the retinohypothalamic tract is the intrinsically photosensitive retinal ganglion cells (ipRGC), which contain the photopigment melanopsin. The axons of the ipRGCs belonging to the retinohypothalamic tract project directly, monosynaptically, to the suprachiasmatic nuclei (SCN) via the optic nerve and the optic chiasm.
The axons of midget cells travel through the optic nerve and optic tract, ultimately synapsing with parvocellular cells in the LGN. These cells are known as midget retinal ganglion cells due to the small sizes of their dendritic trees and cell bodies. About 80% of RGCs are midget cells. They receive inputs from relatively few rods and cones.
Retinal layers, from bottom to top: retinal pigment epithelium (RPE), photoreceptors (PR), horizontal cells (HC), bipolar cells (BC), amacrine cells (AC), ganglion cells (RGC), nerve fiber layer (RNFL). A retinal implant is a visual prosthesis for restoration of sight to patients
The differentiation of retinal precursor cells into the mature cell types found in the retina is coordinated in time and space by factors within the cell as well as factors in the environment of the cell. One example of an intrinsic regulator of this process is the transcription factor Ath5. Ath5 expression in retinal progenitor cells biases ...