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  2. Thiazide - Wikipedia

    en.wikipedia.org/wiki/Thiazide

    The thiazide drug class was discovered and developed at Merck and Co. in the 1950s. [3] The first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. [3] In most countries, thiazides are the least expensive antihypertensive drugs available. [4]

  3. Bisphosphonate - Wikipedia

    en.wikipedia.org/wiki/Bisphosphonate

    Long-term treatment with bisphosphonates produces anti-fracture and bone mineral density effects that persist for 3–5 years after an initial 3–5 years of treatment. [2] The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk of hip fractures by 38% and of vertebral ...

  4. Mineralocorticoid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Mineralocorticoid_receptor...

    Increased urination is a commonly reported side effect, particularly during the initial phase following treatment initiation; this is mostly transient and tends to reduce with sustained treatment. Common side effects for antimineralocorticoid medications include nausea and vomiting, stomach cramps and diarrhoea. [4]

  5. Zoledronic acid - Wikipedia

    en.wikipedia.org/wiki/Zoledronic_acid

    Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired. [3] Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. [3] Use during pregnancy may result in harm to the baby. [3] It is in the bisphosphonate family of medications. [3]

  6. Odanacatib - Wikipedia

    en.wikipedia.org/wiki/Odanacatib

    Odanacatib (INN; [1] codenamed MK-0822) is an investigational treatment for osteoporosis and bone metastasis. [2] It is an inhibitor of cathepsin K , [ 3 ] an enzyme involved in bone resorption . The drug was developed by Merck & Co.

  7. Antidiuretic - Wikipedia

    en.wikipedia.org/wiki/Antidiuretic

    An antidiuretic is a substance that helps to control fluid balance in an animal's body by reducing urination, [1] opposing diuresis. [2] Its effects are opposite that of a diuretic . The major endogenous antidiuretics are antidiuretic hormone (ADH; also called vasopressin) and oxytocin .

  8. Alendronic acid - Wikipedia

    en.wikipedia.org/wiki/Alendronic_acid

    Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.

  9. Pamidronic acid - Wikipedia

    en.wikipedia.org/wiki/Pamidronic_acid

    Common side effects include bone pain, low calcium levels, nausea, and dizziness. Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including pamidronate. [3] Pamidronate activates human γδ T cells in vitro and in vivo, which may lead to flu-like symptoms upon administration.

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