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Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5kDa αhCG and 22.2kDa βhCG. [4]It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and a β (beta) subunit that is unique to hCG.
One likely reason for such high sequence similarity in hCG and LH is the fact that both respective beta subunits both bind to the same receptor, with their homology illustrating a common biological function and biochemical pathway. [6] Amino acid sequence of CGB, with sites of glycosylation, mutation, and phosphorylation notated
No visible IUP on transvaginal ultrasonography with a serum hCG of more than 2000 mIU/mL. An abnormal rise in hCG level. A rise of 35% over 48 hours is proposed as the minimal rise consistent with a viable intrauterine pregnancy. An abnormal fall in hCG level, such as defined as one of less than 20% in two days.
For example, for a starting hCG level of 1,500 mIU/ml or less, the hCG of continuing, normal pregnancy will increase at least 49% in 48 hours. However, for pregnancies with a higher starting hCG, between 1,500 and 3,000 mIU/ml, the hCG should rise at least 40%; for a starting hCG greater than 3,000 mIU/ml, the hCG should increase at least 33%. [30]
Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene. [5]The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently.
Hydatidiform mole (one type of GTD) may also be called molar pregnancy. [citation needed] Persistent disease; persistent GTD: If there is any evidence of persistence of GTD, usually defined as persistent elevation of beta hCG (see Diagnosis above), the condition may also be referred to as gestational trophoblastic neoplasia (GTN). [61]
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Beta human chorionic gonadotrophin (β-hCG) In males and non-pregnant females: 5 [15] ... Slightly less than osmolality: mOsm/L: Plasma volume includes solutes Urea ...
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