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Cis and trans are defined in terms of the geometric relationships of the two unsubstituted phenyl rings. [23] The two isomers of clomifene have different profiles, where the trans-form has activity more similar to tamoxifen while the cis-form behaves more like 17β-estradiol. [7] Cis is approximately ten times more potent than trans.
For this reason, CIS will usually not form a tumor. Rather, the lesion is flat (in the skin, cervix, etc.) or follows the existing architecture of the organ (in the breast, lung, etc.). Exceptions include CIS of the colon (polyps), the bladder (preinvasive papillary cancer), or the breast (ductal carcinoma in situ or lobular carcinoma in situ).
Cisgenesis (etymology: cis = same side; and genesis = origin) is one term for organisms that have been engineered using a process in which genes are artificially transferred between organisms that could otherwise be conventionally bred. [2] [3] Genes are only transferred between closely related organisms. [4]
Enhancers work as cis-regulatory elements to mediate both spatial and temporal control of development by turning on transcription in specific cells and/or repressing it in other cells. Thus, the particular combination of transcription factors and other DNA-binding proteins in a developing tissue controls which genes will be expressed in that ...
One cis-regulatory element can regulate several genes, [2] and conversely, one gene can have several cis-regulatory modules. [3] Cis-regulatory modules carry out their function by integrating the active transcription factors and the associated co-factors at a specific time and place in the cell where this information is read and an output is ...
In that case, he “forcibly raped” the teen after taking her back to his cabin when she needed a restroom — then pushed her “face first” onto the bed and raped her, prosecutors said.
In a recent Newsweek article, Alex Beene, a financial literacy instructor at the University of Tennessee at Martin, said, “Many in the real estate business are elated with a Trump victory, and ...
President-elect Donald Trump, after rejecting House Speaker Mike Johnson's plan to avoid a government shutdown, worked the phones on Thursday, showing wavering confidence in Johnson and claiming ...