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The classical cannabinoids are concentrated in a viscous resin produced in structures known as glandular trichomes. At least 113 different cannabinoids have been isolated from the Cannabis plant. [6] All classes derive from cannabigerol-type (CBG) compounds and differ mainly in the way this precursor is cyclized. [21]
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
Cannabinoids and their K i values [a] Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x) JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± ...
The production of the cannabinoids THC and CBD are a result of a series of chemical reactions, and are just two types of over a hundred that are known. [ 9 ] [ 10 ] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [ 9 ]
The number of research projects and scientific publications on cannabidiol and other cannabinoids in pets surged in the late 2010s; nonetheless, as of December 2020, there were no hemp-derived, cannabinoid-rich registered veterinary medicinal products in any of the major regions (see #Legal status).
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
H2CBD (diHydroCBD, partially hydrogenated CBD) are cannabinoids that were first synthesized by Alexander R. Todd in 1940 by catalytic hydrogenation of cannabidiol. [1]The term "H2CBD" can refer to two different chemical compounds that differ by the site of hydrogenation, either saturated on the cyclohexenyl ring (i.e. 1,2-dihydrocannabidiol using the older terpenoid numbering scheme) or ...
HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol [2] by a group led by Raphael Mechoulam at the Hebrew University. [3] [4] [5] HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action. [6]