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Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch . [ 1 ] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
The vaccine completed a Phase I double-blind randomized controlled clinical trial that demonstrated that rBCG30 was safe and immunogenic; during nine months of follow-up, rBCG30, but not BCG, induced significantly increased Antigen 85B-specific immune responses in eight immunological assays (blood lymphocyte proliferation, antibody responses by ELISA, interferon-gamma producing CD4+ and CD8+ T ...
M72/AS01 E is an experimental tuberculosis vaccine. If approved, it would be the first vaccine for tuberculosis in more than a century after the BCG vaccine. [1] [2] The vaccine consists of two main ingredients. The antigen part is M72, a recombinant fusion protein derived from the sequences of two M. tuberculosis antigens (Mtb32A and Mtb39A ).
MVA85A was generally well tolerated and the vaccine had a safety profile comparable to other pediatric vaccines. The most frequent side effect observed was mild redness or swelling around the ...
The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [9] It is named after its inventors Albert Calmette and Camille Guérin. [10] [11] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [9]
The only vaccine, called the BCG vaccine, is used mainly in high-risk areas to protect babies from one form of the disease. Century-old TB vaccine may work better if given in a new way Skip to ...
Immunisation against infectious disease, popularly known as The Green Book, provides information on vaccines for vaccine-preventable diseases. It acts as a guide to the UK's vaccination schedule for health professionals and health departments that give vaccines in the United Kingdom. The first two editions were published in 1992 and 1996.
The main advantage of using live vaccines based on rational attenuation of M. tuberculosis is their ability to keep the genetic repertoire encoding immunodominant antigens that are absent in BCG, [4] whereas chromosomal deletions in virulence genes provide assurance for safety and genetic stability. Such vaccines are expected to safely induce ...