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Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch . [ 1 ] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
The MTBVAC clinical development started with a first-in-human study in healthy adult volunteers in Lausanne, Switzerland (NCT02013245); [12] followed by one additional Phase 1 study in healthy newborns in South Africa in collaboration with South African TuBerculosis Vaccine Initiative (SATVI) (NCT02729571) [13] to corroborate the safety and ...
MVA85A (modified vaccinia Ankara 85A) is a vaccine against tuberculosis developed by researchers led by Professor Helen McShane at Oxford University. [1] It is a viral vector vaccine and consists of an MVA virus engineered to express the 85A antigen once it infects a host cell. 85A is a cell-wall protein of the tuberculosis bacillus.
The vaccine completed a Phase I double-blind randomized controlled clinical trial that demonstrated that rBCG30 was safe and immunogenic; during nine months of follow-up, rBCG30, but not BCG, induced significantly increased Antigen 85B-specific immune responses in eight immunological assays (blood lymphocyte proliferation, antibody responses by ELISA, interferon-gamma producing CD4+ and CD8+ T ...
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The only vaccine, called the BCG vaccine, is used mainly in high-risk areas to protect babies from one form of the disease. Century-old TB vaccine may work better if given in a new way Skip to ...
The bacteria that causes tuberculosis can spread through the air when a person with an active case coughs, sneezes or speaks. The treatment process can take three to nine months, according to the ...
“A serogroup B meningococcal (MenB) vaccine series may be administered to adolescents and young adults 16 through 23 years of age to provide short term protection against most strains of serogroup B meningococcal disease. The preferred age for MenB vaccination is 16 through 18 years of age. (Category B)” [6] The motion was passed, 14 to 1.