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Half maximal inhibitory concentration (IC 50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro , a given biological process or biological component by 50% ...
It is used to measure the Minimum Inhibitory Concentration [MIC] of an antimicrobial agent, which is the lowest concentration of antimicrobial agent that will inhibit the growth of microbes. The turbidity of the tubes indicates the amount of microbe growth, with the least turbid, or clear, tubes (tubes 6 and 7) correlating with the absence of ...
In microbiology, the minimum inhibitory concentration (MIC) is the lowest concentration of a chemical, usually a drug, which prevents visible in vitro growth of bacteria or fungi. [ 1 ] [ 2 ] MIC testing is performed in both diagnostic [ 1 ] [ 2 ] and drug discovery laboratories.
The minimum inhibitory concentration, which is the lowest concentration of the antibiotic that stops the growth of bacteria, can be estimated from the size of the zone of inhibition. Antibiotic susceptibility testing has been needed since the discovery of the beta-lactam antibiotic penicillin. Initial methods were phenotypic, and involved ...
C min is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses.
Biological responses to ligand concentrations typically follow a sigmoidal function. The inflection point at which the increase in response with increasing ligand concentration begins to slow is the EC 50, which can be mathematically determined by derivation of the best-fit line. While relying on a graph for estimation is more convenient, this ...
An alternative assessment is to measure the Minimum inhibitory concentrations (MICs) of disinfectants against selected (and representative) microbial species, such as through the use of microbroth dilution testing. [14] However, those methods are obtained at standard inoculum levels without considering the inoculum effect.
Cefpodoxime has been used to treat gonorrhoea, tonsillitis, pneumonia, and bronchitis. The following minimum inhibitory concentrations have been reported: [2] Haemophilus influenzae: ≤0.03 – 1 μg/ml; Neisseria gonorrhoeae: 0.004 – 0.06 μg/ml; Streptococcus pyogenes: ≤0.004 – 2 μg/ml
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