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2. β-Endorphin - Wikipedia

   en.wikipedia.org/wiki/Β-endorphin

   Substance P is a believed to help sensitize postsynaptic neurons to glutamate, aiding in the transmission of pain signals from periphery nerves to the brain. [16] These neurotransmitters are vital in the transmission of pain, and as β-Endorphin reduces the release of these substances, there is a strong analgesic effect.

3. Endorphins - Wikipedia

   en.wikipedia.org/wiki/Endorphins

   Endorphins inhibit transmission of pain signals by binding μ-receptors of peripheral nerves, which block their release of neurotransmitter substance P. The mechanism in the CNS is similar but works by blocking a different neurotransmitter: gamma-aminobutyric acid (GABA).

4. Substance P - Wikipedia

   en.wikipedia.org/wiki/Substance_P

   Substance P and the NK1-receptor are widely distributed in the brain and are found in brain regions that are specific to regulating emotion (hypothalamus, amygdala, and the periaqueductal gray). [12] They are found in close association with serotonin (5-HT) and neurons containing norepinephrine that are targeted by the currently used ...

5. Enkephalin - Wikipedia

   en.wikipedia.org/wiki/Enkephalin

   In response to pain, norepinephrine, a hormone that is activated in fight-or-flight response, is released along with endorphins. [4] A 2017 study indicates that this polypeptide may be linked to brain functioning during the stress response, especially in the hippocampus and prefrontal cortex.

6. Ziconotide - Wikipedia

   en.wikipedia.org/wiki/Ziconotide

   Ziconotide, sold under the brand name Prialt, also called intrathecal ziconotide (ITZ) because of its administration route, is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide. [2]

7. Accused CEO shooter Luigi Mangione complained about back pain ...

   www.aol.com/news/accused-ceo-shooter-luigi...

   The Ivy League grad accused of fatally shooting UnitedHealthcare CEO Brian Thompson reportedly detailed his health woes, including debilitating back pain and “brain fog,” in a series of Reddit ...