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With SSRIs, duration of treatment does not appear associated with the severity of withdrawal symptoms. [24] One hypothesis is that after the antidepressant is discontinued, there is a temporary (but in some cases long-lasting) deficiency in the brain of one or more essential neurotransmitters that regulate mood, such as serotonin, dopamine ...
SSRI use in pregnancy is associated with an increased risk of spontaneous abortion of about 1.7-fold. [ 141 ] [ 142 ] Use is also associated with preterm birth . [ 143 ] According to some researches, decreased body weight of the child, intrauterine growth retardation, neonatal adaptive syndrome, and persistent pulmonary hypertension also was noted.
Antidepressant withdrawal syndrome may occur if stopped. [10] There are concerns that use during the later part of pregnancy can harm the developing fetus. [10] Duloxetine was approved for medical use in the United States [10] [13] and the European Union in 2004. [5] [7] It is available as a generic medication. [12]
The major limitation of SSRIs concerns their delay of action. It appears that the clinical efficacy of SSRIs becomes evident only after a few weeks. [217] SSRIs can be combined with a host of other drugs including bupropion, α 2 adrenergic antagonists (e.g., yohimbine) as well as some of the atypical antipsychotics. The augmentation agents are ...
If your antidepressant isn’t working after several weeks or is causing side effects, you might not need to change to a new medication. Your healthcare provider may suggest a different dosage or ...
Generally, tapering is done is to avoid or minimize withdrawal symptoms that arise from neurobiological adaptation to the drug. [1] [2] Prescribed psychotropic drugs that may require tapering due to this physical dependence include opioids, [3] [4] [5] selective serotonin reuptake inhibitors, [6] antipsychotics, [7] anticonvulsants, [8] and ...
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Neonatal withdrawal or neonatal abstinence syndrome (NAS) or neonatal opioid withdrawal syndrome (NOWS) is a drug withdrawal syndrome of infants, caused by the cessation of the administration of drugs which may or may not be licit.