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1559 72303 Ensembl ENSG00000138109 ENSMUSG00000067231 UniProt P11712 n/a RefSeq (mRNA) NM_000771 NM_028191 RefSeq (protein) NP_000762 n/a Location (UCSC) Chr 10: 94.94 – 94.99 Mb Chr 19: 39.05 – 39.08 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by ...
Meloxicam has been shown, especially at low therapeutic doses, to selectively inhibit COX-2 over COX-1. [9] Meloxicam concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid compared to plasma.
It has an apparent volume of distribution (V D) of 455 +/- 166 L in humans and the area under the plasma concentration-time curve increases proportionally to increased oral doses, between 100 and 800 mg. Celecoxib is metabolized primarily by CYP2C9 isoenzyme to carboxylic acid and also by non-CYP-dependent glucuronidation to glucuronide ...
The existing nonsteroidal anti-inflammatory drugs differ in their relative specificities for COX-2 and COX-1; while aspirin and ibuprofen inhibit COX-2 and COX-1 enzymes, other NSAIDs appear to have partial COX-2 specificity, particularly meloxicam . [39] Aspirin is ≈170-fold more potent in inhibiting COX-1 than COX-2. [40]
CYP2C9 and CYP2S1 are known to, and many or all of the other CYPs that act on arachidonic acid are thought to, metabolize the 18 carbon essential fatty acid 9(Z),12(Z)-octadecadienoic acid, i.e. linoleic acid, at its 12,13 carbon–carbon double bonds to form (+) and (-) epoxy optical isomers viz., the 12S,13R-epoxy-9(Z)-octadecenoic and 12R ...
Enzyme Inhibitors Inducers; CYP1A1: Certain foods (e.g., cumin, turmeric) Certain herbs/herbal teas (e.g., peppermint, German chamomile, dandelion, Kava) Amiodarone ...
Noncompetitive inhibitors of CYP2C9 enzyme include nifedipine, tranylcypromine, phenethyl isothiocyanate, and 6-hydroxyflavone. Computer docking simulation and constructed mutants substituted indicate that the noncompetitive binding site of 6-hydroxyflavone is the reported allosteric binding site of CYP2C9 enzyme. [9]
Bucolome (Paramidine) is a barbiturate derivative. Unlike most barbiturates it does not have any significant sedative or hypnotic effects, but instead acts as an analgesic and antiinflammatory.
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