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Neramexane is a drug related to memantine, [1] which acts as an NMDA antagonist [2] and has neuroprotective effects. [3] It is being developed for various possible applications, including treatment of tinnitus, [4] [5] Alzheimer's disease, [6] drug addiction [7] and as an analgesic. [8]
The adverse effects found in the Phase II trial mainly affected the central nervous system, and appeared to be dose-related. [8] The most common adverse effects were drowsiness, dizziness, tinnitus and vertigo, confusion, and slurred speech. [9] Less common side effects included tremor, memory loss, gait disturbances, and double vision. [10]
In 2020, information about clinical trials indicated that bimodal neuromodulation may reduce the symptoms of tinnitus. It is a noninvasive technique that involves applying an electrical stimulus to the tongue while also administering sounds. [ 129 ]
Since 1980, the organization has granted around $6 million in seed funding for tinnitus research. [7] Many of the researchers have utilized their ATA-funded research data to apply for and receive larger, federally-funded grants from the Department of Defense, National Science Foundation, and the National Institute on Deafness and Other Communications Disorders (NIDCD), part of the NIH.
Medication costs can be the selling price from the manufacturer, that price together with shipping, the wholesale price, the retail price, and the dispensed price. [3]The dispensed price or prescription cost is defined as a cost which the patient has to pay to get medicines or treatments which are written as directions on prescription by a prescribers. [4]
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It is one of only a few drugs that has a beneficial effect in the chronic treatment of the vertigo and tinnitus associated with Ménière's disease. [12] In a clinical study (n=181), treatment with cinnarizine reduced the occurrence of moderate vertigo experience by 65.8% and extreme vertigo by 89.8%. [8]
Tinnitus activities treatment (TAT) is a clinical adaptation of TRT that focuses on four areas: thoughts and emotions, hearing and communication, sleep, and concentration. [ 13 ] Progressive tinnitus management (PTM) is a five-step structured clinical protocol for management of tinnitus that may include tinnitus retraining therapy.
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