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Although a number of surrogate biomarkers exist for measuring the metabolic products of bone resorption, the serum CTX marker was chosen because it is both highly correlated to bone turnover rate and already available for detection in a laboratory test carried out by a major lab testing corporation.
The N-terminal telopeptide (NTX), also known as amino-terminal collagen crosslinks, is the N-terminal telopeptide of fibrillar collagens such as collagen type I and type II.It is used as a biomarker to measure the rate of bone turnover.
Richard Eastell (born 12 February 1953) is a British medical doctor and Professor of Bone Metabolism at the University of Sheffield. [1] He was born in Shipley (West Yorkshire) and attended the Salt Grammar School, [citation needed] later graduating from the University of Edinburgh in 1977 with an MB ChB and in 1984 with an MD [2] and achieved prominence as an expert in osteoporosis.
12845 Ensembl ENSG00000105664 ENSMUSG00000031849 UniProt P49747 Q9R0G6 RefSeq (mRNA) NM_000095 NM_016685 RefSeq (protein) NP_000086 NP_057894 Location (UCSC) Chr 19: 18.78 – 18.79 Mb Chr 8: 70.83 – 70.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ...
where, is a convolution operator, C bone (t) is the bone tissue activity concentration of tracer (in units: MBq/ml) over a period of time t, C plasma (t) is the plasma concentration of tracer (in units: MBq/ml) over a period of time t, IRF(t) is equal to the sum of exponentials, β values are fixed between 0.0001 sec −1 and 0.1 sec −1 in ...
The trabecular bone score is a measure of bone texture correlated with bone microarchitecture and a marker for the risk of osteoporosis. Introduced in 2008, [ 1 ] its main projected use is alongside measures of bone density in better predicting fracture risk in people with metabolic bone problems.
Markers of bone turnover in urine eg. Pyridinoline; Elevated levels of serum and urinary hydroxyproline are also found. Bone scans are useful in determining the extent and activity of the condition. If a bone scan suggests Paget's disease, the affected bone(s) should be X-rayed to confirm the diagnosis.
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid [5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. [6] Because osteocalcin has gla domains, its synthesis is vitamin K-dependent. In humans, osteocalcin is encoded by the ...