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While cannabis is generally considered a calming drug, a recent study found heavy use could have the opposite effect — potentially worsening anxiety and associated disorders.
Here’s where science currently stands on the use of marijuana for pain, sleep, anxiety, ... When it comes to easing the symptoms of anxiety, depression and other mental disorders, the analysis ...
A 2020 study published in the Journal of Translational Medicine noted that THC—the main psychoactive ingredient in cannabis—has been noted to increase anxiety, while CBD—a cannabis ...
The psychoactive component of cannabis, tetrahydrocannabinol (THC) is not effective in treating emotion-regulation and anxiety-related symptoms. [20] Conversely, THC has been empirically related to an increase anxiety symptoms through impacts on neurological areas impacting serotonin, noradrenalin, GABA and glutamate. [20] [21] [22] [23]
Some report anxiety only after not smoking cannabis for a prolonged period of time. [38] Inexperience and use in an unfamiliar environment are major contributing factors to this anxiety. Cannabidiol (CBD), another cannabinoid found in cannabis, has been shown to mitigate THC's adverse effects, including anxiety.
People sometimes use cannabis to cope with their anxiety, and cannabis withdrawal can lead to symptoms of anxiety. [58] Buspirone, a serotonin 5-HT 1A receptor partial agonist, has shown limited efficacy for treating anxiety in people with cannabis use disorder, though there may be better efficacy in males than in females. [58]
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