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Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [ 5 ] [ 6 ] [ 7 ] Hox-C6 expression is highest in the fallopian tube and ovary. [ 8 ] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body.
HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4. [7] Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer. [8]
This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21.32 region. [6] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer ) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.
The Cdx protein family is a group of the transcription factor proteins which bind to DNA to regulate the expression of genes. [1] In particular this family of proteins can regulate the Hox genes . They are regulators of embryonic development and hematopoiesis in vertebrates, and are also involved in the development of some types of ...
15417 Ensembl ENSG00000170689 ENSMUSG00000020875 UniProt P17482 P20615 RefSeq (mRNA) NM_024017 NM_008270 RefSeq (protein) NP_076922 NP_032296 Location (UCSC) Chr 17: 48.62 – 48.63 Mb Chr 11: 96.16 – 96.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene. Function This gene is a member of the Abd-B ...
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15422 Ensembl ENSG00000123364 ENSMUSG00000001655 UniProt P31276 P50207 RefSeq (mRNA) NM_017410 NM_010464 RefSeq (protein) NP_059106 NP_034594 Location (UCSC) Chr 12: 53.94 – 53.95 Mb Chr 15: 102.83 – 102.84 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene. Function This gene belongs to the homeobox ...