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Apoptosis (from Ancient Greek: ἀπόπτωσις, romanized: apóptōsis, lit. 'falling off') is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. [1] Biochemical events lead to characteristic cell changes and death. [2]
Apoptosis is the processor of programmed cell death (PCD) that may occur in multicellular organisms. [6] Biochemical events lead to characteristic cell changes ( morphology ) and death. These changes include blebbing , cell shrinkage, nuclear fragmentation, chromatin condensation , and chromosomal DNA fragmentation.
Apoptosis is the process of programmed cell death (PCD) that may occur in multicellular organisms. [12] Biochemical events lead to characteristic cell changes ( morphology ) and death. These changes include blebbing , cell shrinkage, nuclear fragmentation, chromatin condensation , and chromosomal DNA fragmentation.
Cells with a defective G 2-M checkpoint will undergo apoptosis or death after cell division if they enter the M phase before repairing their DNA. [1] The defining biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly and bring the cell to metaphase. [2]
Cell death occurs when the severity of the injury exceeds the cell's ability to repair itself. [2] Cell death is relative to both the length of exposure to a harmful stimulus and the severity of the damage caused. [1] Cell death may occur by necrosis or apoptosis.
The presence or absence of particular apoptotic event(s), including DNA fragmentation, depends on the "time window" at which the kinetic process of apoptosis is being investigated. Often this may complicate identification of apoptotic cells if cell populations are analyzed only at a single time point e.g. after induction of apoptosis.
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Blebbing is one of the defined features of apoptosis. [6] During apoptosis (programmed cell death), the cell's cytoskeleton breaks up and causes the membrane to bulge outward. [13] These bulges may separate from the cell, taking a portion of cytoplasm with them, to become known as apoptotic blebs. [14]
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