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Chemotherapy is teratogenic during pregnancy, especially during the first trimester, to the extent that abortion usually is recommended if pregnancy in this period is found during chemotherapy. [117]
Use during pregnancy may result in harm to the fetus. [8] Melphalan belongs to the class of nitrogen mustard alkylating agents. [7] It works by interfering with the creation of DNA and RNA. [7] Melphalan was approved for medical use in the United States in 1964. [7] It is on the World Health Organization's List of Essential Medicines. [9]
Opioid use during pregnancy may cause adverse outcomes for the women and unborn child. [11] Women who use opioids during pregnancy in a non-medical fashion are at a higher risk for premature birth, lower birth weight, still birth, specific birth defects, and withdrawal (neonatal abstinence syndrome). [11]
Use during pregnancy will likely result in fetal harm. [2] Gemcitabine is in the nucleoside analog family of medication. [2] It works by blocking the creation of new DNA, which results in cell death. [2] Gemcitabine was patented in 1983 and was approved for medical use in 1995. [6] Generic versions were introduced in Europe in 2009 and in the ...
There are concerns that use during pregnancy may cause birth defects. [12] [11] Paclitaxel is in the taxane family of medications. [13] It works by interference with the normal function of microtubules during cell division. [11] Paclitaxel was isolated in 1971 from the Pacific yew and approved for medical use in 1993.
Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered or taken during pregnancy. [6] It causes skeletal deformities such as amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs).
The incidence of pregnancy-associated cancer has risen due to the increasing age of pregnant mothers. [62] Cancers may also be detected incidentally during maternal screening. [62] Cancer treatment needs to be selected to do least harm to both the woman and her embryo/fetus. In some cases a therapeutic abortion may be recommended.
Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. [3] This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. [3] It is used by injection into a vein. [3] Side effects generally occur. [3]
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