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  2. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    The removal of ethanol (drinking alcohol) through oxidation by alcohol dehydrogenase in the liver from the human body is limited. Hence the removal of a large concentration of alcohol from blood may follow zero-order kinetics. Also the rate-limiting steps for one substance may be in common with other substances.

  3. Pharmacology of ethanol - Wikipedia

    en.wikipedia.org/wiki/Pharmacology_of_ethanol

    [4] [6] Alcohol dehydrogenase and aldehyde dehydrogenase are present at their highest concentrations (in liver mitochondria). [98] [107] But these enzymes are widely expressed throughout the body, such as in the stomach and small intestine. [2] Some alcohol undergoes a first pass of metabolism in these areas, before it ever enters the ...

  4. Elimination (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Elimination_(pharmacology)

    The other elimination pathways are less important in the elimination of drugs, except in very specific cases, such as the respiratory tract for alcohol or anaesthetic gases. The case of mother's milk is of special importance. The liver and kidneys of newly born infants are relatively undeveloped and they are highly sensitive to a drug's toxic ...

  5. First pass effect - Wikipedia

    en.wikipedia.org/wiki/First_pass_effect

    The liver is the major site of first pass effect; however, it can also occur in the lungs, vasculature or other metabolically active tissues in the body. Notable drugs that experience a significant first pass effect are buprenorphine , chlorpromazine , cimetidine , diazepam , ethanol (drinking alcohol), imipramine , insulin , lidocaine ...

  6. Detoxification - Wikipedia

    en.wikipedia.org/wiki/Detoxification

    Alcohol detoxification is a process by which a heavy drinker's system is brought back to normal after being habituated to having alcohol in the body continuously for an extended period of substance abuse. Serious alcohol addiction results in a downregulation of GABA neurotransmitter receptors.

  7. 6 ways your brain and body benefit when you stop drinking alcohol

    www.aol.com/finance/6-ways-brain-body-benefit...

    But even one drink a day, considered moderate drinking, increases your risk for certain types of cancer. What's more, alcohol contributes to more than 200 diseases, including in the liver ...

  8. Here's Exactly What Happens to Your Body When You Drink ... - AOL

    www.aol.com/heres-exactly-happens-body-drink...

    Going from hot to cold places can also affect the body, and alcohol doesn't help. "One factor that can play a role is consuming alcohol while in a hot tub, jacuzzi or sauna or drinking outside on ...

  9. Dry January: Experts explain what a month without alcohol can ...

    www.aol.com/lifestyle/dry-january-experts...

    Alcohol is toxic to a lot of organ systems in the body," Oesterle says. "It can affect the liver, pancreas, heart and the nervous system, just to name a few.