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2. Pain ladder - Wikipedia

   en.wikipedia.org/wiki/Pain_ladder

   The WHO guidelines recommend prompt oral administration of drugs ("by the mouth") when pain occurs, starting, if the patient is not in severe pain, with non-opioid drugs such as paracetamol (acetaminophen) or aspirin, [1] with or without "adjuvants" such as non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors.

3. Vertex non-opioid painkiller meets main goal in late ... - AOL

   www.aol.com/news/vertex-non-opioid-pain-drug...

   (Reuters) -Vertex Pharmaceuticals' experimental drug reduced acute, post-surgical pain without the risk of addiction, a major milestone in the company's decades-long efforts to bring a non-opioid ...

4. Analgesic - Wikipedia

   en.wikipedia.org/wiki/Analgesic

   An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...

5. Vertex Pharma scientist talks about the long road to ... - AOL

   www.aol.com/lifestyle/vertex-pharma-scientist...

   Vertex Pharmaceuticals recently reported positive results for a non-opioid painkiller, one of several medications the Boston-based drugmaker has been developing for various forms of pain. Patients ...

6. Suzetrigine - Wikipedia

   en.wikipedia.org/wiki/Suzetrigine

   Suzetrigine (developmental code name VX-548) is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Na v 1.8-dependent pain-signaling pathways in the peripheral nervous system. [1] [2] It is being developed by Vertex Pharmaceuticals and has completed two phase 3 clinical trials. [1] [3]

7. Latigo Biotherapeutics raises $135 million for non-opioid ...

   www.aol.com/news/latigo-biotherapeutics-raises...

   Latigo Biotherapeutics emerged from stealth mode on Wednesday and said it had raised $135 million in series A funding to advance clinical trials of its non-opioid pain treatments, including a drug ...