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M8524/3 Infiltrating lobular mixed with other types of carcinoma (C50._) M8525/3 Polymorphous low grade adenocarcinoma Terminal duct adenocarcinoma; M8530/3 Inflammatory carcinoma (C50._) Inflammatory adenocarcinoma; M8540/3 Paget disease, mammary (C50._) Paget disease of breast; M8541/3 Paget disease and infiltrating duct carcinoma of breast ...
Alpelisib is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.
Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
Ruxolitinib (sold under the brand names Jakafi and Jakavi among others, and as Opzelura in cream form) is a medication used for the treatment of intermediate or high-risk myelofibrosis, [6] a type of myeloproliferative neoplasm that affects the bone marrow; [11] [12] polycythemia vera, when there has been an inadequate response to or intolerance of hydroxyurea; [6] [13] and steroid-refractory ...
In August 2017, the FDA approved a new indication for ibrutinib to treat graft-versus-host disease. It was the first drug approved by the FDA for this condition. [12] [13] [33] In February 2018, a tablet formulation of ibrutinib was approved for use in the United States. [34]
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Alectinib (INN [8]), sold under the brand name Alecensa, is an anticancer medication that is used to treat non-small-cell lung cancer (NSCLC). [6] [7] It blocks the activity of anaplastic lymphoma kinase (ALK).