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Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. [ 5 ] [ 6 ] [ 7 ] In humans it is coded for by the MYO5A gene .
Myosin VI is an unconventional myosin motor, which is primarily processive as a dimer, but also acts as a nonprocessive monomer. It walks along actin filaments, travelling towards the pointed end (- end) of the filaments. [44] Myosin VI is thought to transport endocytic vesicles into the cell. [45]
17919 Ensembl ENSG00000167306 ENSMUSG00000025885 UniProt Q9ULV0 P21271 RefSeq (mRNA) NM_001080467 NM_008661 NM_201600 RefSeq (protein) NP_001073936 n/a Location (UCSC) Chr 18: 49.82 – 50.2 Mb Chr 18: 74.57 – 74.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans. Recent evidence suggests that Myosin-Vb is ...
Myosin II is an elongated protein that is formed from two heavy chains with motor heads and two light chains. Each myosin head contains actin and ATP binding site. The myosin heads bind and hydrolyze ATP, which provides the energy to walk toward the plus end of an actin filament. Myosin II are also vital in the process of cell division. For ...
Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene. [ 5 ] [ 6 ] [ 7 ] Myosin is a hexameric ATPase cellular motor protein . It is composed of two heavy chains , two nonphosphorylatable alkali light chains , and two phosphorylatable regulatory light chains.
With regards to human anatomy myosin and actin constitute the basic functional unit of a muscle fiber, called sarcomere, playing a role in muscle contraction. Biochemically viewed meromyosin form subunits of the actin -associated motor protein , myosin , as commonly obtained by trypsin proteolysis (protein breakdown). [ 1 ]
In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments.
The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle [7] and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin ...