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[5] [6] The human cochlea contains on the order of 3,500 inner hair cells and 12,000 outer hair cells at birth. [7] The outer hair cells mechanically amplify low-level sound that enters the cochlea. [8] [9] The amplification may be powered by the movement of their hair bundles, or by an electrically driven motility of their cell bodies.
The cochlear amplifier is a positive feedback mechanism within the cochlea that provides acute sensitivity in the mammalian auditory system. [1] The main component of the cochlear amplifier is the outer hair cell (OHC) which increases the amplitude and frequency selectivity of sound vibrations using electromechanical feedback.
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
Hensen's cells are important in ion metabolism and homeostasis regulation of both endolymph and perilymph, modulation of the hearing sensitivity, regulation and regeneration of the hair cells, and prevention of the cochlea damage. [6] The outer hair cells of the cochlea preprocess the signal by active movements, which can be elevated by ...
For one, the tall hair cell is very similar in function to that of the inner hair cell, and the short hair cell, lacking afferent auditory-nerve fiber innervation, resembles the outer hair cell. One unavoidable difference, however, is that while all hair cells are attached to a tectorial membrane in birds, only the outer hair cells are attached ...
There are two types of hair cells specific to the auditory system; inner and outer hair cells. Inner hair cells are the mechanoreceptors for hearing: they transduce the vibration of sound into electrical activity in nerve fibers, which is transmitted to the brain. Outer hair cells are a motor structure.
Prestin is the motor protein of the outer hair cells of the inner ear of the mammalian cochlea. [5] It is highly expressed in the outer hair cells, and is not expressed in the nonmotile inner hair cells. Immunolocalization shows prestin is expressed in the lateral plasma membrane of the outer hair cells, the region where electromotility occurs ...
The hair cells are attached to the basilar membrane, and with the moving of the basilar membrane, the tectorial membrane and the hair cells are also moving, with the stereocilia bending with the relative motion of the tectorial membrane. This can cause opening and closing of the mechanically gated potassium channels on the cilia of the hair ...
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