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For example, discontinuation of paroxetine in mice leads to anxiety-like behavior, together with a rebound over-activation of 5-HT neurons. [28] One problem is that many animal studies use fluoxetine as the study drug, despite it being not very commonly associated with withdrawal in human patients.
Knowledge of potential withdrawal symptoms can guide physicians and patients in determining the optimal times to start, adjust, and discontinue medications.” – Joao L. de Quevedo, MD, PhD
Antidepressant discontinuation syndrome, also called antidepressant withdrawal syndrome, is a condition that can occur following the interruption, reduction, or discontinuation of antidepressant medication. [187] The symptoms may include flu-like symptoms, trouble sleeping, nausea, poor balance, sensory changes, and anxiety.
Medication discontinuation is the ceasing of a medication treatment for a patient by either the clinician or the patient themself. [1] [2] When initiated by the clinician, it is known as deprescribing. [3] Medication discontinuation is an important medical practice that may be motivated by a number of reasons: [4] [3] Reducing polypharmacy
Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. [181] [182] Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from the ...
Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [7] used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual dysphoric disorder. [7]
Paroxetine. Also known as the brand name drug Paxil (and others), paroxetine is prescribed to treat social anxiety, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder and ...
Upon the discontinuation of serotonergic drugs, most cases of SS resolve within 24 hours, [6] [9] [73] [74] although in some cases delirium may persist for a number of days. [31] Symptoms typically persist for a longer time frame in patients taking drugs which have a long elimination half-life , active metabolites, or a protracted duration of ...