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Trazodone, sold under many brand names, [ 1 ] is an antidepressant medication, [ 20 ] used to treat major depressive disorder, anxiety disorders, and insomnia. [ 20 ] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. [ 21 ][ 22 ] The medication is taken orally.
However, many are associated with an infamous side effect: weight gain. Luckily, some antidepressants are less likely to cause weight gain than others. In fact, there are even some antidepressants ...
The typical adult gains an average of 1 to 2 pounds per year, which over time, can contribute to obesity. This weight gain can be driven by physical inactivity, stress, poor sleep and poor food ...
In addition, the study was observational, meaning that it cannot prove cause, like that certain antidepressants cause weight gain or loss. Again, while researchers sought to focus on first-time ...
[6] [7] Although it can also cause weight gain, the risk is much lower than for other atypical antipsychotics. [8] How it works is not entirely clear but is believed to involve effects on serotonin and dopamine in the brain. [5] Ziprasidone was approved for medical use in the United States in 2001. [5]
Serotonin has been implicated as a critical factor in the short-term regulation of food intake and in promoting loss of weight associated with hyperphagia. [9] Studies using pharmacological and genetic tools demonstrated that the 5-HT 2C receptor subtype was one of the principal mediators through which serotonin exerts its anorectic effects in ...
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At six months of usage, Lexapro, Paxil and Cymbalta users were 10% to 15% more likely to gain at least 5% of their starting weight than Zoloft consumers, the study found.