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The BK virus rarely causes disease but is typically associated with patients who have had a kidney transplant; many people who are infected with this virus are asymptomatic. If symptoms do appear, they tend to be mild: respiratory infection or fever. These are known as primary BK infections.
Graft and patient survival after transplantation have also improved over time, with 10 year graft survival rates for deceased donor transplants increasing from 42.3% in 1996–1999 to 53.6% in 2008-2011 and 10 year patient survival rate increasing from 60.5% in 1996–1999 to 66.9% in 2008–2011. [79]
Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney transplant is the only treatment option. Chronic kidney disease is defined as prolonged kidney abnormalities (functional and/or structural in nature) that last for more than three months. [ 1 ]
Overall postoperative complications after kidney transplantation occur in approximately 12% to 25% of kidney transplant patients. [ 34 ] Following a transplant, recipients will be given lab draws , ultrasounds , and other tests to see if the transplanted organ is being accepted .
The 1-year mortality rate in patients who have end-stage kidney disease is 45-80%. [1] Median survival in patients who do not have end-stage kidney disease is 4.2 months. [19] Response to treatment is not guaranteed. The most common cause of death in calciphylaxis patients is sepsis, severe infection originating from a non-healing ulcer. [1]
A novel approach to organ transplantation allowed patients to wean off anti-rejection drugs after two years, according to the results of a phase 3 clinical trial presented Monday.
In the context of chronic kidney disease, they are more accurately viewed as life-extending treatments, although if chronic kidney disease is managed well with dialysis and a compatible graft is found early and is successfully transplanted, the clinical course can be quite favorable, with life expectancy of many years.
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