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Bellergal is a combination of levorotatory alkaloids of belladonna, ergotamine tartrate, and phenobarbital, [1] [2] used for the treatment of functional menopause, such as hot flashes and night sweat. Belladonna, including atropine, hyoscyamine and scopolamine, are antimuscarinic agents. They block acetylcholine from binding to its receptors.
Steigmann and Kaminski [11] examined the antisecretory effect of 0.1296 mg belladonna alkaloids + 16.2 mg phenobarbital (Donnatal®) in peptic ulcer patients, motility in a subgroup of patients and clinical effects in all patients (N =176). Of the IBS patients (n =66), a reported good response with complete relief was found in 53% of male ...
The name Belladonna, meaning beautiful ladies, was derived from women using berry juice from the plant cosmetically to dilate their pupils. [ 4 ] The mydriatic effect was studied by the German chemist Friedlieb Ferdinand Runge (1795-1867), in which the active ingredient, atropine , was first discovered by Vaquelin in 1809 and was first isolated ...
Atropa bella-donna flower. Atropa bella-donna is a branching herbaceous perennial rhizomatous hemicryptophyte, often growing as a subshrub from a fleshy rootstock. Plants can reach a height of 2 m (7 ft) (more commonly 1.5 m (5 ft)), and have ovate leaves up to 18 cm (7 in) long.
Effects of anticholinergic drugs include: Delirium (often with hallucinations and delusions indistinguishable from reality); Ocular symptoms (from eye drops): mydriasis, pupil dilation, and acute angle-closure glaucoma in those with shallow anterior chamber [11] [12] [13]
The toxic berry of Atropa belladonna which contains the tropane deliriants scopolamine, atropine, and hyoscyamine.. Deliriants are a subclass of hallucinogen.The term was coined in the early 1980s to distinguish these drugs from psychedelics such as LSD and dissociatives such as ketamine, due to their primary effect of causing delirium, as opposed to the more lucid (i.e. rational thought is ...
The name "belladonna", Italian for "beautiful lady", is thought to derive from one of the antimuscarinic effects of these alkaloids: they were used by women for cosmetic purposes, to promote dilation of the pupils. [2] Muscarinic antagonist effects and muscarinic agonist effects counterbalance each other for homeostasis.
Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including henbane, mandrake, angel's trumpets, jimsonweed, the sorcerers' tree, and Atropa belladonna (deadly nightshade).
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