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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Plasma perhexiline concentrations as low as 0.6mg/L> are known to cause nausea and dizziness; however, perhexiline is also known to cause hepatotoxicity and peripheral neuropathy at plasma concentrations >0.6mg/L. [9] [10] The symptoms of peripheral neuropathy include weakness or sensory loss and pain in the arms, hand, legs, and feet.
Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). Subcategories ...
NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.
The reasoning so far is simple: Just as a GLP-1 can make eating food less enjoyable because it modulates your brain’s pleasure and reward center, doctors say that it could impact how you feel ...
Related: 12 Foods That Are Good For Your Liver. ... (Epigallocatechin-3-gallate, one of the catechins in green tea) were more likely to cause hepatotoxicity," Dr. Kim notes. "For comparison, a cup ...
It can also cause liver damage. [5] [6] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). [5] [8] It has strong anabolic effects and weak androgenic effects. [5]