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2. Ivabradine - Wikipedia

   en.wikipedia.org/wiki/Ivabradine

   Patients who qualify for use of ivabradine for coronary heart failure are patients who have symptomatic heart failure, with reduced ejection volume, and heart rate at least 70 bpm, and the condition not able to be fully managed by beta blockers. [3] Ivabradine acts by allowing negative chronotropy in the sinoatrial structure, thus reducing the ...

3. Sacubitril/valsartan - Wikipedia

   en.wikipedia.org/wiki/Sacubitril/valsartan

   Sacubitril/valsartan can be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure and a reduced left ventricular ejection fraction (LVEF), [17] [9] alongside other standard therapies (e.g. beta-blockers) for heart failure.

4. Cardiovascular agents - Wikipedia

   en.wikipedia.org/wiki/Cardiovascular_agents

   Special attention should be given to the coadministration of non-DHP with beta-blockers or ivabradine due to the increased risk of bradycardia. [13] Since both DHP and non-DHP are metabolized through the CYP3A4 system, grapefruit juice containing furanocoumarins (the potent inhibitors of the CYP3A4 enzyme) should be avoided.

5. Beta blocker - Wikipedia

   en.wikipedia.org/wiki/Beta_blocker

   Beta blockers vary in their lipophilicity (fat solubility) and in turn in their ability to cross the blood–brain barrier and exert effects in the central nervous system. [76] Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects ...

6. Atrial fibrillation - Wikipedia

   en.wikipedia.org/wiki/Atrial_fibrillation

   Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]

7. Adrenergic blocking agent - Wikipedia

   en.wikipedia.org/wiki/Adrenergic_blocking_agent

   The combination of beta blockers and antihypertensive drugs will work on different mechanism to lower blood pressure. [17] For example, the co-administration of beta-1 blocker atenolol and ACE inhibitor lisinopril could produce a 50% larger reduction in blood pressure than using either drug alone. [18]