Ad
related to: erythrocyte transketolase
Search results
Results from the WOW.Com Content Network
Transketolase (abbreviated as TK) is an enzyme that, in humans, is encoded by the TKT gene. [1] It participates in both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis .
Wernicke-Korsakoff syndrome (WKS) is the combined presence of Wernicke encephalopathy (WE) and alcoholic Korsakoff syndrome (AKS [clarification needed]).Due to the close relationship between these two disorders, people with either are usually diagnosed with WKS as a single syndrome.
Thiamine can be measured using an erythrocyte transketolase activity assay, [6] or by activation by measurement of in vitro thiamine diphosphate levels. [6] Normal thiamine levels do not necessarily rule out the presence of WE, [6] as this may be a patient with difficulties in intracellular transport.
Erythrocytes, for example, generate a large amount of NADPH through the pentose phosphate pathway to use in the reduction of glutathione. Hydrogen peroxide is also generated for phagocytes in a process often referred to as a respiratory burst .
74419 Ensembl ENSG00000151005 ENSMUSG00000025519 UniProt Q9H0I9 Q9D4D4 RefSeq (mRNA) NM_032136 NM_001271574 NM_028927 RefSeq (protein) NP_115512 NP_001258503 NP_083203 Location (UCSC) Chr 4: 163.47 – 163.47 Mb Chr 8: 66.96 – 66.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transketolase-like protein 2 is an enzyme that in humans is encoded by the TKTL2 gene. References ^ a b ...
In what is essentially the reverse of step two, the electrons push back in the opposite direction forming a new bond between the substrate carbon and another atom. (In the case of the decarboxylases, this creates a new carbon-hydrogen bond. In the case of transketolase, this attacks a new substrate molecule to form a new carbon-carbon bond.)
The SIRT2-mediated deacetylation and activation of G6PD stimulates pentose phosphate pathway to supply cytosolic NADPH to counteract oxidative damage and protect mouse erythrocytes. [16] Regulation can also occur through genetic pathways. The isoform, G6PDH, is regulated by transcription and posttranscription factors. [17]
Transketolase-like-1 (TKTL1) is a gene closely related to the transketolase gene (TKT). It emerged in mammals during the course of evolution and, according to the latest research findings, is considered one of the key genes that distinguishes modern humans ( Homo sapiens ) from Neanderthals .
Ad
related to: erythrocyte transketolase