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[50] [51] Systematic reviews and meta‐analysis of randomized controlled trials of intravenous administration of high doses of vitamin C (such as 12 g, every 12 hours for 7 days) in mild, moderate, severe, and critically ill COVID-19 patients concluded that vitamin C administration did not influence disease severity or mortality in comparison ...
There is no evidence to indicate that intravenous ascorbic acid therapy can cure cancer. [33] [32] According to the U.S. Food and Drug Administration (FDA), high-dose vitamin C (such as intravenous ascorbic acid therapy) has not been approved as a treatment for cancer or any other medical condition. [2]
A review of clinical trials in the treatment of colds with small and large doses of Vitamin C has established that there is no evidence that it decreases the incidence of common colds. [28] After 33 years of research, it is still not established whether vitamin C can be used as a treatment for cancer. [29]
The NIH recommends that most adults consume no more than 100 total micrograms of vitamin D per day. At very high doses, vitamin D may contribute to a range of side effects and complications ...
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Taking a daily multivitamin can also provide a little additional vitamin C, often about 100 mg per supplement, so an additional high dose vitamin C supplement is not necessary,” says Braslow.
Reviews list trials with doses as high as 24 grams per day. [127] Concerns about possible adverse effects are that intravenous high-dose vitamin C leads to a supraphysiological level of vitamin C followed by oxidative degradation to dehydroascorbic acid and hence to oxalate, increasing the risk of oxalate kidney stones and oxalate nephropathy.
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