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If a drug can inhibit telomerase in cancer cells, the telomeres of successive generations will progressively shorten, limiting tumor growth. [56] Telomerase is a good biomarker for cancer detection because most human cancer cells express high levels of it. Telomerase activity can be identified by its catalytic protein domain .
In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells. [9] Telomerase can be reactivated and telomeres restored to the embryonic state by somatic cell nuclear transfer. [18]
Still, the blood values are approximately equal between the arterial and venous sides for most substances, with the exception of acid–base, blood gases and drugs (used in therapeutic drug monitoring (TDM) assays). [6] Arterial levels for drugs are generally higher than venous levels because of extraction while passing through tissues. [6]
In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells. Telomerase can be reactivated and telomeres reset back to an embryonic state by somatic cell nuclear transfer . [ 18 ]
Increasing the telomerase activities in stem cells gives different effects depending on the intrinsic nature of the different types of stem cells. [18] Hence, not all stem cells will have increased stem-cell properties. For example, research has shown that telomerase can be upregulated in CD34+ Umbilical Cord Blood Cells through hTERT over ...
10220 14561 Ensembl ENSG00000135414 ENSMUSG00000025352 UniProt O95390 Q9Z1W4 RefSeq (mRNA) NM_005811 NM_010272 RefSeq (protein) NP_005802 NP_034402 Location (UCSC) Chr 12: 55.74 – 55.76 Mb Chr 10: 128.72 – 128.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in ...
Over 45 for men and over 55 for women. Family history. Having a family history of early heart disease. Sex. ... Having your cholesterol levels and blood pressure regularly checked.
To measure the concentrations of TRF1 and the relationships among telomere length, telomerase activity, and TRF1 levels in tumor and normal colorectal mucosa, from normal and tumoral samples of patients who underwent surgery for colorectal cancer we analyzed TRF1 protein concentration, and telomerase activity were analysed.