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Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The precise mechanism by which zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium and T-type calcium channels , which leads to the suppression of neuronal hypersynchronization ...
Benzodiazepines act as a central nervous system depressant. The relative strength of each of these properties in any given benzodiazepine varies greatly and influences the indications for which it is prescribed. Long-term use can be problematic due to the development of tolerance to the anticonvulsant effects and dependency.
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker ...
Early decision (ED) or early acceptance is a type of early admission used in college admissions in the United States for admitting freshmen to undergraduate programs.It is used to indicate to the university or college that the candidate considers that institution to be their top choice through a binding commitment to enroll; in other words, if offered admission under an ED program, and the ...
If you’re stuck on today’s Wordle answer, we’re here to help—but beware of spoilers for Wordle 1255 ahead. Let's start with a few hints.
Related: Clay Aiken 'Left Music' 10 Years Ago.How Recording a New Christmas Album 'Opened' His 'Eyes' Again (Exclusive) "Back then it was a big deal," says Aiken, who recently marked his return to ...
Ziconotide was discovered in the early 1980s by University of Utah research scientist Michael McIntosh, [3] when he was barely out of high school and working with Baldomero Olivera. [ 4 ] Ziconotide was developed into an artificially manufactured drug by Elan Corporation.
"And that form may kind of evolve and change, and there is a way in which we can all be in that form," she added. "And I'm grateful, 'cause it's not just me — it has to require everybody to be ...