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Produces roughly as much weight gain as risperidone, less weight gain than clozapine, olanzapine and zotepine and more weight gain than ziprasidone, lurasidone, aripiprazole and asenapine. [22] As with many other atypical antipsychotics, this action is likely due to its actions at the H 1 histamine receptor and 5-HT 2C receptor .
Trazodone is usually used at a dosage of 150 to 300 mg/day for the treatment of depression. [ 17 ] [ 13 ] Lower doses have also been used to augment other antidepressants or when initiating therapy. [ 17 ] [ 13 ] Higher doses, up to 600 mg/day, have been used in more severe cases of depression (in hospitalized patients, for example). [ 29 ]
[4] [5] Antipsychotics like quetiapine and olanzapine and antidepressants like trazodone and mirtazapine are all potent serotonin 5-HT 2A receptor antagonists. [ 6 ] [ 28 ] [ 29 ] Conversely, benzodiazepines and alcohol act as positive allosteric modulators of the GABA A receptor and have anxiolytic and sedative effects. [ 30 ]
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
Changes in appetite or weight are common among antidepressants but are largely drug-dependent and related to which neurotransmitters they affect. Mirtazapine and paroxetine, for example, may be associated with weight gain and/or increased appetite, [178] [179] [180] while others (such as bupropion and venlafaxine) achieve the opposite effect ...
Management is based primarily on stopping the usage of the precipitating drugs, the administration of serotonin antagonists such as cyproheptadine (with a regimen of 12 mg for the initial dose followed by 2 mg every 2 hours until clinical, while some claim that a higher initial dose up to 32 mg has more benefit [65]), [66] and supportive care ...
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]
The meeting was called due to concerns that 10–100,000 people could be dependent; meeting chairman Professor Malcolm Lader later revised this estimate to include approximately half a million members of the British public suspected of being dependent on therapeutic dose levels of benzodiazepines, with about half of those on long-term ...
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related to: trazodone vs seroquel weight gain dose dependentThe lowest prices on specific drugs - Family Circle