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Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). [2] [3] Most people are infected by the virus as children, when the disease produces few or no symptoms. [2] In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and ...
See also Infectious mononucleosis and the other diseases listed in this section EBV causes infectious mononucleosis. [ 56 ] Children infected with EBV have few symptoms or can appear asymptomatic, but when infection is delayed to adolescence or adulthood, it can cause fatigue , fever , inflamed throat , swollen lymph nodes in the neck, enlarged ...
There are several forms of Epstein–Barr virus (EBV) infection. These include asymptomatic infections, the primary infection, infectious mononucleosis, and the progression of asymptomatic or primary infections to: 1) any one of various Epstein–Barr virus-associated lymphoproliferative diseases such as chronic active EBV infection, EBV+ hemophagocytic lymphohistiocytosis, Burkitt's lymphoma ...
[1] [2] The virus establishes latent infection and causes infectious mononucleosis. There is also increasingly more evidence that EBV may be a trigger of multiple sclerosis. [3] It is a dual-tropic virus, meaning that it infects two different host cell types — in this case, both B cells and epithelial cells.
Infectious mononucleosis ("glandular fever") is caused by the Epstein–Barr virus. This may cause significant lymph-node swelling and an exudative tonsillitis with marked redness and swelling of the throat. The heterophile test can be used if this is suspected. Herpes simplex virus can cause multiple mouth ulcers. Measles
After its initial entry into B cells, the Epstein–Barr virus infects other B cells and in doing so may or may not cause a symptomatic disease viz., infectious mononucleosis. In either case, the virus soon switches to its dormant, viral latency 0 phase within memory B cells and the infected individual becomes an asymptomatic, lifelong EBV ...
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This was recognized as a clinical syndrome in the 1800s consisting of fever, pharyngitis and adenopathy. The term glandular fever was first used in 1889 and the association with Epstein-Barr virus infection in the late 1960s. Sprunt and Evans described the characteristics of Epstein-Barr virus infectious mononucleosis in 1920.