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Sotatercept, sold under the brand name Winrevair is a medication used for the treatment of pulmonary arterial hypertension. [5] It is an activin signaling inhibitor, [ 5 ] based on the extracellular domain of the activin type 2 receptor expressed as a recombinant fusion protein with immunoglobulin Fc domain (ACTRIIA-Fc). [ 8 ]
Luspatercept, sold under the brand name Reblozyl, is a medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes. [5]
Acceleron Pharma, Inc. is an American clinical stage biopharmaceutical company based in Cambridge, Massachusetts with a broad focus on developing medicines that regulate the transforming growth factor beta (TGF-β) superfamily of proteins, which play fundamental roles in the growth and repair of cells and tissues such as red blood cells, muscle, bone, and blood vessels.
The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions.
Visual definition of an antagonist, where it compared to agonists and reverse agonists. An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors.
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11481 Ensembl ENSG00000114739 ENSMUSG00000061393 UniProt Q13705 P27040 RefSeq (mRNA) NM_001106 NM_007397 NM_001313757 RefSeq (protein) NP_001097 NP_001300686 NP_031423 Location (UCSC) Chr 3: 38.45 – 38.49 Mb Chr 9: 119.23 – 119.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an ...
Comparing Oral vs. Injectable Semaglutide. It’s hard to watch the news or scroll through social media without encountering stories about weight loss drugs like semaglutide (the active ingredient ...