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[6] [5] Fluconazole is in the azole antifungal family of medication. [5] It is believed to work by affecting the fungal cellular membrane. [5] Fluconazole was patented in 1981 and came into commercial use in 1988. [7] It is on the World Health Organization's List of Essential Medicines. [8] Fluconazole is available as a generic medication. [5]
The current first-line treatment is fluconazole, 200 mg on the first day, followed by daily dosing of 100 mg for at least 21 days total.Treatment should continue for 14 days after relief of symptoms.
Some fungi (e.g. Candida krusei and fluconazole) exhibit intrinsic resistance to certain antifungal drugs or classes, whereas some species develop antifungal resistance to external pressures. Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals ...
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Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
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twice daily bib. bibe: drink bis bis: twice b.i.d., b.d. bis in die: twice daily AMA style avoids use of this abbreviation (spell out "twice a day") bis ind. bis indies: twice a day bis in 7 d. bis in septem diebus: twice a week BM bowel movement: commonly used in the United Kingdom when discussing blood sugar.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261