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In the wake of the establishment of the normal number of human chromosomes, 47,XYY was the last of the common sex chromosome aneuploidies to be discovered, two years after the discoveries of 47,XXY, [27] 45,X [28] and 47,XXX [29] in 1959. Even the much less common 48,XXYY [30] had been discovered in 1960, a year before 47,XYY.
Past thoughts on genetic factors influencing aggression, specifically in regard to sex chromosomes, tended to seek answers from chromosomal abnormalities. [4] Four decades ago, the XYY genotype was (erroneously) believed by many to be correlated with aggression.
The presentation of XYYY syndrome is variable and at this time not entirely clear. As all known cases were diagnosed postnatally (after birth), and the similar XYY syndrome is known to have a milder phenotype in prenatally than postnatally diagnosed cases, it is suspected that many cases of XYYY syndrome may be mild or asymptomatic.
Sex chromosome aneuploidies [note 1] are generally associated with tall stature, particularly polysomies of the Y chromosome, but data on tetrasomy and pentasomy disorders [note 2] is less clear and some seem associated with short stature; [6] [7] adult XXXYY men in the medical literature have ranged in height from 170 centimetres (5 ft 7 in ...
Sex chromosome anomalies belong to a group of genetic conditions that are caused or affected by the loss, damage or addition of one or both sex chromosomes (also called gonosomes). In humans this may refer to: 45, X, also known as Turner syndrome; 45,X/46,XY mosaicism, also known as X0/XY mosaicism and mixed gonadal dysgenesis; 46, XX/XY
In 1967 the MRC in Edinburgh launched a longitudinal study of infants, in order to determine the prevalence of sex chromosome disorders and to track outcomes of people born with them; the study was launched due to sensational publications claiming that XYY males were doomed to become aggressive and criminal adults. [4]
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XYYYY syndrome, also known as 49,XYYYY, is an exceptionally rare chromosomal disorder in which a male human has three additional copies of the Y chromosome. Only seven non- mosaic cases of the disorder have ever been recorded in the medical literature, as well as five mosaic cases, of which two had more 48,XYYY than 49,XYYYY cells. [ 1 ]