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For example, gout in ankles or gout in knee joints may also occur. ... If you have untreated gout for a long time, something called tophi can develop. Tophi is when uric acid crystals around the ...
Do you sometimes have severe, unexplained pain in your joints, particularly in your big toe, ankle, or knee? The post Managing Out-of-Control Chronic Gout: Going Beyond Oral Treatments appeared ...
A tophus (Latin: "stone", pl.: tophi) is a deposit of monosodium urate crystals, in people with longstanding high levels of uric acid (urate) in the blood, a condition known as hyperuricemia. Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of ...
Without treatment, episodes of acute gout may develop into chronic gout with destruction of joint surfaces, joint deformity, and painless tophi. [5] These tophi occur in 30% of those who are untreated for five years, often in the helix of the ear, over the olecranon processes, or on the Achilles tendons. [5] With aggressive treatment, they may ...
In gout, probenecid competitively inhibits the reabsorption of uric acid through the organic anion transporter (OAT) at the proximal tubules. This leads to preferential reabsorption of probenecid back into plasma and excretion of uric acid in urine, [ 6 ] thus reducing blood uric acid levels and reducing its deposition in various tissues.
Pegloticase (trade name Krystexxa) is a medication for the treatment of severe, treatment-refractory, chronic gout. It is a third line treatment in those in whom other treatments are not effective or are not tolerated. [2] The drug is administered by infusion intravenously. Since October 2023, Amgen Inc. has been the marketer of pegloticase in ...
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