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Gram-negative: Third-generation cephalosporins have a broad spectrum of activity and further increased activity against gram-negative organisms. They may be particularly useful in treating hospital-acquired infections, although increasing levels of extended-spectrum beta-lactamases are reducing the clinical utility of this class of antibiotics.
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
Cefpodoxime is an oral, third-generation cephalosporin antibiotic available in various generic preparations. It is active against both Gram-positive and Gram-negative organisms with notable exceptions including Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.
C. Carbacephem; Cefacetrile; Cefaclor; Cefadroxil; Cefalexin; Cefaloglycin; Cefalonium; Cefalotin; Cefamandole; Cefaparole; Cefapirin; Cefatrizine; Cefazaflur; Cefazedone
Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [4] These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. [4]
Print/export Download as PDF; Printable version; In other projects ... or cephradine is a first generation cephalosporin antibiotic. [1] Indications
Cefoxitin is a beta-lactam antibiotic which binds to penicillin binding proteins, or transpeptidases. By binding to PBPs, cefoxitin prevents the PBPs from forming the cross-linkages between the peptidoglycan layers that make up the bacterial cell wall, thereby interfering with cell wall synthesis.
Cefalotin / ˌ s ɛ f ə ˈ l oʊ t ɪ n / or cephalothin / ˌ s ɛ f ə ˈ l oʊ θ ɪ n / is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity. [1] [2] It was the first cephalosporin marketed (1964) and continues to be widely used. [3]