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Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Treatment is stopped when ulceration and crusting appear. There is minimal scarring. Complete clearance has been reported in about 50% of patients. [13] Imiquimod (Aldara) is an immune response modifier that has been studied for the treatment of actinic cheilitis. It promotes an immune response in the skin leading to apoptosis (death) of the ...
Identifying and treatment the underlying malignancy constitutes an uptime approach. Topical 5-fluorouracil may occasionally be help, as may oral retinoids, topical steroids, vitamin A acid, urea, salicylic acid, podophyllotoxin, and cryodestruction employing liquid. [citation needed]
Surgery to remove the basal-cell carcinoma affected area and the surrounding skin is thought to be the most effective treatment. [40] A disadvantage with standard surgical excision is a reported higher recurrence rate of basal-cell cancers of the face, [ 41 ] especially around the eyelids, [ 42 ] nose, and facial structures. [ 43 ]
Oral retinoids (e.g., acitretin, [4] [12] [13] etretinate [14]) may be helpful in treating arsenic-induced cutaneous lesions and in reducing the risk of cutaneous and internal malignancy formation, especially in Bowman's disease. Topical 5-fluorouracil cream [13] or 5% imiquimod cream [15] may be useful in treating arsenical keratoses and Bowen ...
Perioral dermatitis, also known as periorificial dermatitis, is a common type of inflammatory skin rash. [2] Symptoms include multiple small (1–2 mm) bumps and blisters sometimes with background redness and scale, localized to the skin around the mouth and nostrils.
Topical chemotherapies, such as 5-fluorouracil, are used to treat some cases of non-melanoma skin cancer. [ 74 ] If the cancer has central nervous system involvement, or with meningeal disease, intrathecal chemotherapy may be administered.
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU. [1] It was patented in 1967 and approved for medical use in 1972. [2]
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