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The AIDS epidemic, caused by HIV (Human Immunodeficiency Virus), found its way to the United States between the 1970s and 1980s, [2] but was first noticed after doctors discovered clusters of Kaposi's sarcoma and pneumocystis pneumonia in homosexual men in Los Angeles, New York City, and San Francisco in 1981.
From 2010 to 2020, HIV infections increased by 21% in Latin America, 22% in the Middle East and North Africa, and 72% in Eastern Europe and central Asia. [ 8 ] Most people in North America and western and central Europe with HIV are able to access treatment and live long and healthy lives. [ 13 ]
HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells. [88] HIV is a member of the genus Lentivirus, [89] part of the family Retroviridae. [90] Lentiviruses share many morphological and biological characteristics.
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Reagan did not publicly acknowledge AIDS until 1985 and did not give an address on it until 1987. Reports on AIDS from Surgeon General C. Everett Koop in 1986 and a commission led by James D. Watkins in 1988 were provided to the Reagan administration and offered information about AIDS and policy suggestions on how to limit its spread.
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The discovery of the main HIV/SIV phylogenetic relationships permits explaining broad HIV biogeography: the early centres of the HIV-1 groups were in Central Africa, where the primate reservoirs of the related SIVcpz and SIVgor viruses (chimpanzees and gorillas) exist; similarly, the HIV-2 groups had their centres in West Africa, where sooty ...
The specimen, named DRC60 contained a strain of HIV-1 around 88% similar to LEO70, but was found to be most closely related to HIV-1 (M) subgroup A isolates. These two specimens are significant not only because they are the oldest known specimens of HIV-1, but because they show that the virus already had an extensive amount of genetic diversity ...