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Altitude sickness, the mildest form being acute mountain sickness (AMS), is a harmful effect of high altitude, caused by rapid exposure to low amounts of oxygen at high elevation. [ 1 ] [ 2 ] [ 3 ] People's bodies can respond to high altitude in different ways.
Very high altitude = 3,500–5,500 metres (11,500–18,000 ft) Extreme altitude = above 5,500 metres (18,000 ft) Travel to each of these altitude regions can lead to medical problems, from the mild symptoms of acute mountain sickness to the potentially fatal high-altitude pulmonary edema and high-altitude cerebral edema .
[1] [2] Research at high altitude is also an important way to learn about sea level conditions that are caused or complicated by hypoxia such as chronic lung disease and sepsis. Patients with these conditions are very complex and usually suffer from several other diseases at the same time, so it is virtually impossible to work out which of ...
High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic pulmonary edema that occurs in otherwise healthy people at altitudes typically above 2,500 meters (8,200 ft). [2] HAPE is a severe presentation of altitude sickness. Cases have also been reported between 1,500–2,500 metres or 4,900–8,200 feet in people who ...
Genetic evidence suggests that the Tibetan peoples diverged from the larger Han Chinese population any time around 1,000 B.C.E. [29] [30] [31] to 7,000 B.C.E. [32] [33] Given the significant mutations to the EPAS1 gene that contribute to the Tibetan resistance to altitude sickness, this suggests that the extreme evolutionary pressure on the ...
Mountain sickness can refer to: Altitude sickness or acute mountain sickness, a pathological condition that is caused by acute exposure to low air pressure Chronic mountain sickness , a disease that can develop during extended time living at altitude
Failure to acclimatize may result in altitude sickness, including high-altitude pulmonary edema or cerebral edema . [11] [12] Humans have survived for 2 years at 5,950 m (19,520 ft) [475 millibars (14.0 inHg; 6.89 psi) of atmospheric pressure], which appears to be near the limit of the permanently tolerable highest altitude. [13]
People can become acclimatised to an altitude of 5,200 to 5,500 metres (17,000 to 18,000 ft) if they remain at high altitude for long enough, but for high altitude rescue work, rescue teams must be rapidly deployed, and the time necessary to acclimatise is not available, making oxygen breathing equipment necessary above approximately 3,700 ...