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  2. Aminoglycoside - Wikipedia

    en.wikipedia.org/wiki/Aminoglycoside

    Spectinomycin, a related but distinct chemical structure class often discussed with aminoglycosides, does not induce mRNA misreading and is generally not bactericidal.) [8] It has been proposed that aminoglycoside antibiotics cause oxidation of guanine nucleotides in the bacterial nucleotide pool, and that this contributes to the cytotoxicity ...

  3. Amikacin - Wikipedia

    en.wikipedia.org/wiki/Amikacin

    Side-effects of amikacin are similar to those of other aminoglycosides. Kidney damage and ototoxicity (which can lead to hearing loss) are the most important effects, occurring in 1–10% of users. [17] The nephro- and ototoxicity are thought to be due to aminoglycosides' tendency to accumulate in the kidneys and inner ear. [8] Diagram of the ...

  4. Gentamicin - Wikipedia

    en.wikipedia.org/wiki/Gentamicin

    Gentamicin is a type of aminoglycoside [5] and works by disrupting the ability of the bacteria to make proteins, which typically kills the bacteria. [ 5 ] Gentamicin is naturally produced by the bacterium Micromonospora purpurea , [ 9 ] [ 5 ] was patented in 1962, approved for medical use in 1964. [ 10 ]

  5. Streptomycin - Wikipedia

    en.wikipedia.org/wiki/Streptomycin

    Streptomycin is an aminoglycoside. [3] It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death. [3] Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus. [5] [6] It is on the World Health Organization's List of Essential Medicines. [7]

  6. Kanamycin kinase - Wikipedia

    en.wikipedia.org/wiki/Kanamycin_kinase

    Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. [2]

  7. List of antibiotics - Wikipedia

    en.wikipedia.org/wiki/List_of_antibiotics

    Generic name Brand names Common uses [4] Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All ...

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  9. Sisomicin - Wikipedia

    en.wikipedia.org/wiki/Sisomicin

    Sisomicin is the most predictably active aminoglycoside against Gram-positive bacteria. [2] Like most other aminoglycosides, sisomicin is bactericidal for sensitive clinical isolates. The minimum bactericidal concentrations (MBC) have been found to be equivalent or very close to the minimum inhibitory concentrations (MIC). [ 3 ]