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Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
The most common cause of osteomalacia is a deficiency of vitamin D, which is normally derived from sunlight exposure and, to a lesser extent, from the diet. [10] The most specific screening test for vitamin D deficiency in otherwise healthy individuals is a serum 25(OH)D level. [11]
Vitamin D related hypocalcemia may be associated with a lack of vitamin D in the diet, a lack of sufficient UV exposure, or disturbances in renal function. Low vitamin D in the body can lead to a lack of calcium absorption and secondary hyperparathyroidism (hypocalcemia and raised parathyroid hormone). [ 1 ]
On the other hand, CKD-MBD is defined as a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: 1) abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; 2) abnormalities in bone turnover, mineralization, volume, linear growth, or strength (renal osteodystrophy ...
Additionally, they had a serum 25-hydroxy vitamin D level between 10 and 30 ng/mL. Anything below 30 ng/mL is considered insufficient, while values less than 20 are classified as vitamin D deficiency.
Healthcare professionals can diagnose vitamin D deficiency with a 25-hydroxy vitamin D blood test. This test checks for 25-hydroxyvitamin D, a common form of vitamin D that circulates in the blood.
In a study by Mithal et al., [40] vitamin D insufficiency of various countries was measured by lower 25-hydroxyvitamin D. 25(OH) D is an indicator of vitamin D insufficiency that can be easily measured. These percentages should be regarded as relative vitamin D levels, and not as predicting evidence for development of rickets.
They also had a serum 25-hydroxy vitamin D level between 10 and 30 ng/mL, which indicates either “insufficient” vitamin D levels (below 30/mL) or vitamin D deficiency (below 20 ng/mL).
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