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A major measure of kidney function is the glomerular filtration rate (GFR). The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate (C Cr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
The normal range of GFR, adjusted for body surface area, is 100–130 average 125 (mL/min)/(1.73 m 2) in men and 90–120 (mL/min)/(1.73 m 2) in women younger than the age of 40. In children, GFR measured by inulin clearance is 110 (mL/min)/(1.73 m 2) until 2 years of age in both sexes, and then it progressively decreases. After age 40, GFR ...
The primary cause of the lack of clarity surrounding the GFR levels that indicate hyperfiltration is their strong reliance on age. [12] Glomerular hyperfiltration has traditionally been characterized as an elevated whole-kidney GFR, or a GFR greater than two standard deviations above the mean GFR of healthy individuals.
To clinically stage the degree of damage in this (and any) kidney disease, the serum creatinine is determined and used to calculate the estimated glomerular filtration rate . Normal eGFR is equal to or greater than 90ml/min/1.73 m 2. [34] On biopsy, the following classification has been suggested by Tervaert et al.: [35]
This process is called ultrafiltration; the resulting fluid, virtually free of large proteins and blood cells, is referred to as glomerular filtrate, or ultrafiltrate. [1] Further modification of ultrafiltrate, by reabsorption and secretion, transforms it into urine. Glomerular pressure is about 75 millimeters of mercury (10 kPa). It is opposed ...
In renal physiology, the filtration fraction is the ratio of the glomerular filtration rate (GFR) over the renal plasma flow (RPF). Filtration Fraction, FF = GFR/RPF, or =. The filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys that passes into the renal tubules. It is normally about 20%.
Micrograph of proteinaceous material in Bowman's space, which is unspecific. It is present in about 5% of people aged over 60 years, [2] but also in for example hypertensive kidney disease. Measuring the glomerular filtration rate (GFR) is a diagnostic test of kidney function. [3] A decreased GFR may be a sign of kidney failure. [citation needed]
Estimated glomerular filtration rate (eGFR), a measure of renal function Topics referred to by the same term This disambiguation page lists articles associated with the title EGFR .