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  2. N-Desmethyltamoxifen - Wikipedia

    en.wikipedia.org/wiki/N-Desmethyltamoxifen

    N-Desmethyltamoxifen (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). [1] [2] N-Desmethyltamoxifen is further metabolized into endoxifen (4-hydroxy-N-desmethyltamoxifen), which is thought to be the major active form of tamoxifen in the body.

  3. Tamoxifen - Wikipedia

    en.wikipedia.org/wiki/Tamoxifen

    Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. [13] It is also being studied for other types of cancer. [13] It has been used for Albright syndrome. [14] Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14]

  4. Gynecomastia - Wikipedia

    en.wikipedia.org/wiki/Gynecomastia

    Tamoxifen may be used to treat gynecomastia in adults and of the medical treatments used, tamoxifen is the most effective. [61] [62] Recent studies have shown that treatment with tamoxifen may represent a safe and effective mode of treatment in cases of cosmetically disturbing or painful gynecomastia.

  5. The Surprising Reason You Keep Gaining Weight Around ... - AOL

    www.aol.com/heres-why-might-notice-weight...

    “Most of the time, belly fat gain is a reflection of a combination of factors, and less commonly due to one specific hormone,” Dr. Cohn says. But if you notice sudden, excess belly fat that ...

  6. Fatty Liver Disease: What Men Need to Know - AOL

    www.aol.com/fatty-liver-disease-men-know...

    Research suggests that losing three to five percent of your body weight can improve fat build-up, while losing 10 percent can reduce liver inflammation. If you lose weight, you might find your ...

  7. Here's Why You're More Likely To Gain Belly Fat During ... - AOL

    www.aol.com/heres-why-youre-more-likely...

    Menopause belly is weight gain in the midsection due to hormonal changes. But MDs have advice for treating and preventing it in perimenopause and menopause.

  8. Antihormone therapy - Wikipedia

    en.wikipedia.org/wiki/Antihormone_therapy

    Tamoxifen is also thought to lower the risk of breast cancer in those who have a predisposition or at risk. [9] Tamoxifen may be used in pre and postmenopausal women. [10] Toremifene is a similar SERM drug to tamoxifen, but is less common and only approved for treatment of metastatic cancer. Toremifene is generally prescribed once tamoxifen is ...

  9. Endoxifen - Wikipedia

    en.wikipedia.org/wiki/Endoxifen

    Endoxifen is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromatase inhibitors, and fulvestrant). [3] [4] [5] The prodrug tamoxifen is metabolized by the CYP2D6 enzyme to produce endoxifen and afimoxifene (4-hydroxytamoxifen). [6]