Search results
Results from the WOW.Com Content Network
The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
Ethylene glycol, antifreeze, is extremely toxic to dogs. It has a sweet taste and thus dogs will drink it. As little as 2 1/2 tablespoons can kill a medium-sized dog in 2–3 days. This type of poisoning is often fatal as dog owners do not know their pet has ingested the antifreeze. De-icing fluids can also contain ethylene glycol.
Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase, [6] found in the liver. This enzyme plays a key role in the metabolism of ethylene glycol, and of methanol.
The effect of ethanol on dogs and cats is similar to its effect on humans, also causing intoxication. Death is unlikely given supportive care (only one death is known). Ethanol is also an antidote for ethylene glycol poisoning. [47] Mouse and rat poison, anticoagulant type Rodenticide is commonly found in the house or garage.
Vomiting is one of the most common signs of poisoning in dogs, so if there’s a chance your dog could have gotten into something toxic, you should call your vet immediately to discuss. Here are ...
An antidote is a substance that can counteract a form of poisoning. [1] The term ultimately derives from the Greek term φάρμακον ἀντίδοτον (pharmakon antidoton) , "(medicine) given as a remedy".
[3] [4] [5] Taken by mouth or injected into a vein, ethanol is used to treat methanol or ethylene glycol toxicity when fomepizole is not available. [1] Side effects of alcohols applied to the skin include skin irritation. [2] Care should be taken with electrocautery, as ethanol is flammable. [1]
Ethanol may be administered as an antidote to ethylene glycol poisoning [39] and methanol poisoning. [40] It does so by acting as a competitive inhibitor against methanol and ethylene glycol for alcohol dehydrogenase (ADH). [41] Though it has more side effects, ethanol is less expensive and more readily available than fomepizole in the role. [42]