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Xanomeline is an agonist that primarily targets the muscarinic acetylcholine receptor family of five muscarinic receptor subtypes, which are designated M 1-M 5. [2] While it binds with near identical affinity to all five of the muscarinic receptor subtypes as measured by displacement of a muscarinic radioligand, the preponderance of evidence suggests that xanomeline acts preferentially in the ...
The effectiveness of xanomeline/trospium chloride for the treatment of schizophrenia in adults was evaluated in two studies with identical designs. [2] Study 1 (NCT04659161) and study 2 (NCT04738123) were 5-week, randomized, double-blind, placebo-controlled, multi-center studies in adults with a diagnosis of schizophrenia according to DSM-5 ...
The variation has led to the suggestion that treatment responsive and treatment resistant schizophrenia be considered as two different subtypes. [149] [159] It is further suggested that if the subtypes could be distinguished at an early stage significant implications could follow for treatment considerations, and for research. [154]
Mardepodect (developmental code name PF-2545920) is a drug which was developed by Pfizer for the treatment of schizophrenia. It acts as a phosphodiesterase inhibitor selective for the PDE 10A subtype. [1]
The primary treatment of schizophrenia is the use of antipsychotic medications, often in combination with psychosocial interventions and social supports. [ 27 ] [ 185 ] Community support services including drop-in centers, visits by members of a community mental health team , supported employment , [ 186 ] and support groups are common.
And while antipsychotics can help schizophrenia’s “positive” symptoms, such as hallucinations, they have a minimal impact on the “negative” symptoms, which are arguably more devastating. People who have schizophrenia can lose the ability to focus, to sustain effort, to carry on a conversation or to maintain eye contact.
Antipsychotic drug treatment is a key component of schizophrenia treatment recommendations by the National Institute of Health and Care Excellence (NICE), [23] the American Psychiatric Association, [24] and the British Society for Psychopharmacology. [25]
Schizophrenia presents significant challenges, but with diagnosis, treatment, and support, individuals can manage symptoms and lead fulfilling lives. Ask the Expert: Understanding schizophrenia ...