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Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. This condition can rapidly lead to life-threatening infection , as the body cannot produce leukocytes in response to invading bacteria and viruses , as well as leading to anaemia due to a lack of red ...
Other causes of reactive thrombocythemia include: post surgery, iron deficiency, drugs, and rebound effect after bone marrow suppression. [8] Research suggests that thrombocytosis can also occur after physical exercise, and is triggered by hemoconcentration and the release of platelets from the liver, lungs and spleen. [3] [9]
Bone marrow suppression, rhabdomyolysis, embryo-fetal toxicity, capillary leak syndrome, hepatotoxicity [20] 1.10 Platinum compounds: Carboplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific. Ovarian cancer, lung cancer and squamous cell head and neck cancer
Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes. [5] anemia: hemoglobin < 13.5 g/dL (male) or < 12 g/dL (female). leukopenia: total white cell count < 4.0 x 10 9 /L. Decrease in all types of white blood cells (revealed by doing a differential count). thrombocytopenia: platelet count < 150×10 9 /L.
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors , which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency.
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation.As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung injury.
Common side effects include hair loss, vomiting, bone marrow suppression, and inflammation of the inside of the mouth. [2] Other severe side effects include heart disease and tissue death at the site of injection. [2] Use in pregnancy may harm the fetus. [2] Daunorubicin is in the anthracycline family of medication. [3]
A Bone marrow biopsy is also recommended to evaluate bone marrow function to remove concerns or rule out other possible hematologic disorders. [28] The bone marrow usually shows early granulocyte precursors, but myelopoietic development stops ("arrests") at the promyelocyte and/or myelocyte stage, so that few maturing forms are seen. [29]