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Uricosuric medications are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the kidney .
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Co-administration of the following drugs may make allopurinol less active or decrease its half-life: [13] Salicylates and medicines that increase the secretion of uric acid; furosemide (see more on diuretics below) Co-administration of the following drugs may cause hypersensitivity or skin rash: [13] Ampicillin and amoxicillin
Avoid foods that cause gout, including those with high-fructose corn syrup, like sodas, juice drinks, and sweets, which can increase uric acid production. Drink plenty of water to help flush uric ...
Certain drugs, such as thiazide diuretics, can increase blood uric acid levels by interfering with renal clearance. [ 40 ] Tumor lysis syndrome , a metabolic complication of certain cancers or chemotherapy, due to nucleobase and potassium release into the plasma.
Other medications that increase the risk include niacin, aspirin (acetylsalicylic acid), ACE inhibitors, angiotensin receptor blockers, beta blockers, ritonavir, and pyrazinamide. [ 1 ] [ 17 ] The immunosuppressive drugs ciclosporin and tacrolimus are also associated with gout, [ 5 ] the former more so when used in combination with ...
Blood and urine tests that look for uric acid levels, which can be a sign of gout Blood tests for specific markers of autoimmune diseases to verify lupus or rheumatoid arthritis symptoms
Medications that may contribute to the cure or amelioration of hyperuricosuria include allopurinol which acts by inhibiting xanthine oxidase and reducing uric acid production. [2] Hyperuricosuria may be a medical sign of: Gout (very common) Kidney stones of uric acid (uric acid nephrolithiasis) Acute uric acid nephropathy; Acute kidney failure
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